2015 Fiscal Year Final Research Report
The roles and applications of IL-23 and IL-27 in new therapeutic strategies for malignant melanoma and psoriasis
| Project/Area Number |
25461692
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
NAGAI HIROSHI 神戸大学, 医学部附属病院, 講師 (80335447)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO TAKAYUKI 東京医科大学, 医学部, 教授 (80202406)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 乾癬 / 悪性黒色腫 |
|---|
| Outline of Final Research Achievements |
We conducted studies on therapeutic effects of interleukin (IL)-27 on malignant melanoma and psoriasis in murine models. We demonstrated the mechanisms of synergistic antitumor effects induced by intratumoral CD4+ T lymphodepletion and OX40 agonist. We analyzed imiquimod-induced psoriasis-like dermatitis in IL-27 transgenic mice and WSX-1-deficient mice.
|
| Free Research Field |
皮膚科学
|
