2015 Fiscal Year Final Research Report
Study for a mechanism of prolonged CD203c expression-based basophil activation in the patients with red meat allergy
Project/Area Number |
25461693
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Shimane University |
Principal Investigator |
Chinuki Yuko 島根大学, 医学部, 講師 (00294380)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 獣肉アレルギー / マダニ咬傷 / 好塩基球 / CD203c発現定量 / α-Gal |
Outline of Final Research Achievements |
We found that patients with red meat allergy showed prolonged CD203c expression-based basophil activation even if they did not developed allergic reaction. The incidence of red meat allergy is high in Shimane prefecture, as is tick-transmitted Japanese spotted fever. Therefore, we speculated that tick bites may cause these meat allergies. The carbohydrate α-Gal was detected in the salivary gland protein of Haemaphysalis longicornis (H. longicornis), the vector for Japanese spotted fever, by immunoblotting using anti-α-Gal antibody. H. longicornis salivary gland protein-specific IgE was detected in the sera of 24 of 30 patients with red meat allergies. Sensitization to tick salivary gland protein containing α-Gal is possibly a major role in the prolonged CD203c expression-based basophil activation in the patients with red meat allergy.
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Free Research Field |
食物アレルギー
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