2015 Fiscal Year Final Research Report
Malignant melanoma cell kinetics is modulated by adipocyte-cancer cell interaction.
| Project/Area Number |
25461701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TODA Shuji 佐賀大学, 医学部病因病態科学講座, 教授 (80188755)
MISAGO Noriyuki 佐賀大学, 医学部皮膚科学講座, 准教授 (90199977)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 皮膚科学 / 悪性黒色腫 / 脂肪細胞 |
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| Outline of Final Research Achievements |
Malignant melanoma is the most aggressive skin cancer. The effective treatment for advanced cancer patients has not been established. In recent years, the association between obesity and malignant melanoma has been focused in epidemiological studies, but it remains to be elucidated. In the study we used the collagen gel organ culture system utilized with the adipose tissue, and demonstrated that subcutaneous adipose tissue promotes the proliferation of malignant melanoma cells. In addition, the visceral fat tissue may contribute to the invasive ability and melanin production of malignant melanoma cells. According to the present study, adipose tissue was found to contribute deeply to the cell kinetics of malignant melanoma. This organ culture system could be a promising tool for the development and evaluation of new molecular targeted therapies for malignant melanoma.
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| Free Research Field |
病理学
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