2016 Fiscal Year Final Research Report
Roles of protease allergen in epicutaneous sensitization
Project/Area Number |
25461711
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Juntendo University |
Principal Investigator |
Takai Toshiro 順天堂大学, 医学(系)研究科(研究院), 准教授 (70338375)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 経皮感作 / プロテアーゼアレルゲン / アレルギーマーチ / IgE/Th2/Th17 / 皮膚炎症 / バリア破壊 / 模擬引っ掻きモデル / 洗剤モデル |
Outline of Final Research Achievements |
Epicutaneous sensitization has been considered as an important route for sensitization to allergens not only in atopic dermatitis but also towards other allergic diseases such as asthma (atopic march). Allergen sources such as mites and pollen produce or contain proteases, which can stimulate various types of cells. In this study, we established a murine model of epicutaneous sensitization to protease allergen and demonstrated that the protease activity of epicutaneously administered antigen markedly promoted sensitization and skin inflammation towards development of atopic march in airway.
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Free Research Field |
アレルギー学・免疫学・皮膚科学
|