2015 Fiscal Year Final Research Report
Is keratoacanthoma a benign neoplasm?: Retrieval of heterogenity using proteomics.
Project/Area Number |
25461716
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Nippon Medical School |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAITO Zenya 日本医科大学, 大学院医学研究科, 教授 (20237184)
KUDO Mitsuhiro 日本医科大学, 医学部, 講師 (20256978)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | ケラトアカントーマ / 有棘細胞癌 / クレーター状疣贅 / IMP3 / MAPK4 |
Outline of Final Research Achievements |
We classified the tumors with crateriform silhouette like keratoacanthoma (KA) using large amounts of cases. Of these, there were about 20% cases that showed distinctive histopathological feature different from KA. Whereas 56.3% of the cases were KA, about 10% of those were KA with malignant transformation and about 10% of other crateriform malignant neoplasms were also contained. Insulinlike growth factor 2 mRNAbinding protein-3;(IMP3) was positive in about 50% of the cases with SCC, though none of KA was positive. IMP is thought to be new target for treatment and useful marker for differentiation between SCC and KA.
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Free Research Field |
皮膚病理組織学
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