The functional analysis of Chromogranin in the neuropsychiatric diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Neuropsychiatric Research Institute (2014-2015); University of Tsukuba (2013)
• Principal Investigator: Iijima Yoshimi 公益財団法人神経研究所, 研究部, 研究員 (70574648)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオストレスマーカー / 統合失調症 / 筋萎縮性側索硬化症

Outline of Final Research Achievements

In our previous genome-wide association studies, a significant association with schizophrenia was observed at the chromogranin B (CHGB) gene locus. CHGB is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. In this study, I performed analyses as follows: ①The behavioral analyses of chgb-KO mice, ②The functional analyses of CHGB in the amyotrophic lateral sclerosis (ALS) using genetically modified mice, ③ The relationship between psychological stress symptoms and the gene variation of CHGB.

Free Research Field

精神神経化学