2016 Fiscal Year Final Research Report
Genome-wide methylation and association analysis of depression
| Project/Area Number |
25461723
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Teikyo Heisei University (2015-2016)
The University of Tokyo (2013-2014) |
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Principal Investigator |
OTOWA Takeshi 帝京平成大学, 臨床心理学研究科, 教授 (70456119)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 遺伝子 / 全ゲノム関連解析 / うつ状態 / メチル化 |
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| Outline of Final Research Achievements |
The aim of the present study is to identify genes that influence the association of stressful events with depression. Therefore, we performed a genome-wide G × E interaction analysis in the Japanese population living in the Kanto area (n=800) and found a nominally significant association. We also performed an epigenome-wide association study of depression using DNA methylation arrays and found several candidate regions.
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| Free Research Field |
精神科遺伝学
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