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2015 Fiscal Year Final Research Report

Reclassification of schizophrenia by candidate gene and symptom

Research Project

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Project/Area Number 25461731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOkayama University

Principal Investigator

Takaki Manabu  岡山大学, 大学病院, 助教 (60452570)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords統合失調症 / 亜型分類 / 臨床転帰 / 社会転帰 / 遺伝子解析 / PDE4B / リスクアレル / Polygenic risk score
Outline of Final Research Achievements

We investigated the association between genetics and clinical or social outcomes of about 500 patients with schizophrenia at the critical period. Among 7 SNPs of 6 genes (SLC6A5, DTNBP1, GRM7, PPP3CC, EGR3, and PDE4B) which participated in NMDA receptor function, rs894747 of SLC6A5 gene was related to severity of illness and social outcome. Rs472952 of PDE4B gene was related to low score of letter fluency test. In 91SNPs of GWAS analysis of Japanese patients with schizophrenia, each 3SNPs including rs2623659 of CSMD1 was related to severity of illness or social outcome. 3SNPs ralated with severity of illness was also related to treatment resistance. It is interesting that the genetic factor also influenced to the clinical or social outcomes of the patients with schizophrenia.

Free Research Field

精神医学

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Published: 2017-05-10  

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