Development of rational treatment strategy for refractory mood disorders

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461736
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of the Ryukyus
• Principal Investigator: Kondo Tsuyoshi 琉球大学, 医学(系)研究科(研究院), 教授 (40215455)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 難治性気分障害 / ラモトリギン / 有効血漿濃度 / 自閉スペクトラム症 / 自殺リスク / 抑うつ性混合状態

Outline of Final Research Achievements

The following three options of rational treatment strategy for refractory mood disorders were obtained from the present study.
First, minimal effective concentration (12.7µmol/L) of lamotrigine and optimal dose setting by determining drug concentration at 2-week were established in patients with refractory mood disorders receiving lamotrigine augmentation. Second, it was shown that comorbid autism spectrum disorder as a cause of tretament resistance was found in 11-16% of the first-visit depressed adults, who had about 4 times higher risk of attempted suicide with more fatal methods. Finally, two-dimensional structure by static/dynamic and internalized/externalized elements of depressive symptoms in relation to well matched treatment options was proposed for development of quantification of depressive mixed state as a cause of treatment resistant mood disorders.

Free Research Field

臨床精神神経薬理学