The develpoment of biological marker for alcohol-induced mood disorders: focusing on the functional alteration of platelet and neural stem cell

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461737
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: ISHII Takao 札幌医科大学, 医学部, 助教 (40404701)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO ERI 札幌医科大学, 医学部, 准教授 (30301401) ; MATSUYAMA KIYOJI 札幌医科大学, 保健医療学部, 教授 (40209664) ; UKAI WATARU 札幌医科大学, 医学部, 講師 (40381256) ; SOUMA HITOSHI 札幌医科大学, 医療人育成センター, 教授 (70226702)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アルコール / 気分障害 / 脳由来神経栄養因子 / 血小板

Outline of Final Research Achievements

In this study, we investigated the common pathophysiology of alcohol-induced brain damage and mood disorders, focusing on the functional alteration of platelet and neural stem cell. We examine the effects of ethanol and antidepressants on the platelet BDNF release. Ethanol suppressed platelet BDNF release and the promotive effect of antidepressant on BDNF release. Furthermore, we investigated the transfer of BDNF derived from serum (or platelet) to the brain using fluorescent-labeled BDNF. We have detected BDNF-FITC in the cells at dentate gyrus in the hippocampus in which adult neurogenesis occurs.

Free Research Field

精神医学