2015 Fiscal Year Final Research Report
Prediction of pharmacodynamics and plasma levels of enantiomer of antidepressants with population pharmacokinetic analysis
| Project/Area Number |
25461739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | mirtazapine / CYP2D6 / pharmacokinetics / pharmacogenetics |
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| Outline of Final Research Achievements |
We examined effect of the CYP2D6 genetic polymorphism on pharmacokinetics of mirtazapine (MIR) associated with the metabolism of MIR. Plasma levels of S-(+)-MIR, R-(-)-MIR, S-(+)-desmethylmirtazapine (DMIR) and R-(-)-DMIR were measured. The individual having a homozygote of CYP2D6 *10 was found to show significantly high blood level as compared with the individual which did not have CYP2D6*10. Plasma levels of conjugated metabolites of S-(+)-MIR, R-(-)-MIR, S-(+)-MIR;DMIR and R-(-)-DMIR were found to be as approximately 10 times high as those of non-conjugated compound.
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| Free Research Field |
臨床精神薬理学、ゲノム薬理学
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