2015 Fiscal Year Final Research Report
Elucidation of the etiology of and overcoming schizophrenia by applying the investigation of patients with schizophrenia whose L-serine synthesis pathway is disturbed
Project/Area Number |
25461740
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Dokkyo Medical University |
Principal Investigator |
Ozeki Yuji 獨協医科大学, 医学部, 准教授 (90303768)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 統合失調症 / L-セリン / D-セリン / ホスホセリンホスファターゼ / ホスホセリンアミノトランスフェラーゼ / ホスホグリセリン酸デヒドロゲナーゼ |
Outline of Final Research Achievements |
The treatment for schizophrenia has improved, but there are some symptoms which do not improve entirely. The cause of illness remains being unexplained. If the etiology of schizophrenia is elucidated, a treatment and the prophylaxis of schizophrenia will progress. There are various hypotheses, but we hypothesized that the L-serine synthesis pathway might be related with a disease, so we investigated the L-serine synthesis pathway system in the patients. As a result, we found synthetic ability of the synthetases of L-serine increasing in the patients. In addition, we found that quantities of the mRNA expression of the enzymes which synthesize L-serine were decreased in the patients. However, as a whole, the association between such change and blood concentration of L-serine was not found. In future, we are going to investigate the relationship between L-serine synthesis pathway and the blood concentration of L-serine or amino acids related to L-serine.
|
Free Research Field |
精神医学
|