Association between GABA concentration in the brain of and clinical parameter of individuals with high-functioning autism

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: WAKUDA TOMOYASU 浜松医科大学, 医学部附属病院, 講師 (80444355)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040) ; OMATA Kei 浜松医科大学, 光尖端医学教育研究センター, 助教 (20508783) ; TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高機能自閉症 / GABA / PET画像

Outline of Final Research Achievements

The aim of the present study was to measure concentrations of GABA in the brain of　high-functioning autism by means of magnetic resonance spectroscopy (MRS) and to examine the association between GABA concentrations and clinical parameter. The Autism
Diagnostic Observation Schedule (ADOS) module 4, Autism Diagnostic Interview-Revised (ADI-R), and the Sensory Profile (SP) were used to evaluate current and childhood autism symptoms.
We have obtained the license of the use of MEGA-PRESS spectroscopy for the detection of GABA from GE in 2015. Further evaluations with more participants will be required.

Free Research Field

精神医学