2015 Fiscal Year Final Research Report
Development of the prevention of postoperative delirium based on the circadian rhythm stabilization in patients undergoing cardiovascular bypass surgery
| Project/Area Number |
25461770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | メラトニン / ラメルテオン / 術後せん妄予防 / 心血管バイパス術 / サーカディアンリズム |
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| Outline of Final Research Achievements |
Objective: To evaluate if ramelteon prevents postoperative delirium in patients undergoing elective coronary artery bypass grafting. Design: A randomized, open-label study. Participants: A total of 21 patients undergoing elective coronary artery bypass grafting. Intervention: Ramelteon was administered at 9:00 pm for 3 consecutive days included operation date. Measurements: The primary outcome was incidence of postoperative delirium. Secondary outcomes were length of stay in ICU and hospital. Results: The incidence of delirium in the ramelteon group differed significantly from the control group (0% [0/10] vs. 27.3% [3/11]; p = 0.214).Length of stay in ICU in the ramelteon group did not differ significantly from the control group (p = 0.051). Length of stay in hospital in the ramelteon group did not differ significantly from the control group (p = 0.036). Conclusion: Ramelteon might prevent postoperative delirium in patients undergoing elective coronary artery bypass grafting.
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| Free Research Field |
精神医学
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