Neural mechanism of cognitive deficits in an animal model of schizopnrenia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Fukushima Medical University
• Principal Investigator: Jodo Eiichi 福島県立医科大学, 医学部, 准教授 (50211975)
• Co-Investigator(Kenkyū-buntansha): Suzuki Yoshiaki 福島県立医科大学, 医学部, 博士研究員 (80423797)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 前頭前皮質 / 注意 / ユニット活動 / phencyclidine / 動物モデル / 統合失調症

Outline of Final Research Achievements

This study was designed to develop a new measuring system that can measure the function of attentional-set shifting (ASS) with recording unit-activity of neurons in healthy animals and animal models of schizophrenia. We developed an ASS testing system, which uses visual and auditory stimuli that can readily be synchronized with neuronal activity as a discriminative stimulus. Using this system, single-unit activity of the infralimbic region in the medial prefrontal cortex was recorded during performing the task. The results showed that about 27% of neurons recorded exhibited ASS-relevant changes in firing activity, which were classified into 10 different types depending on response characteristics to stimuli.

Free Research Field

神経生理学