The dopamine transporter PET study clarify the mechanism of delusion and develop the objective evaluation method for delusion.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461788
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: Tateno Amane 日本医科大学, 医学部, 准教授 (50297917)
• Co-Investigator(Kenkyū-buntansha): OKUBO YOSHIRO 日本医科大学, 医学研究科, 教授 (20213663)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 妄想性障害 / ドパミントランスポーター / 統合失調症 / 老年期精神障害 / ポジトロンエミッショントモグラフィー

Outline of Final Research Achievements

The role of dopamine transporter (DAT) function in the delusion and hallucination was examined by DAT positron emission tomography (PET). Seventeen geriatric patients with delusional disorder, 8 geriatric patients with schizophrenia, 12 geriatric healthy subjects, 2 young patients with delusional disorder, 6 young patients with schizophrenia and 9 young healthy controls were participated. DAT binding potential (BP) was examined by DAT-PET to compare the DAT function of each groups. Compared to geriatric healthy controls, geriatric patients with delusional disorder showed significantly lower DAT-BP. These results indicated the possibility that the decreased DAT function takes part in the mechanism of delusional disorder in old age period.

Free Research Field

精神医学