2016 Fiscal Year Final Research Report
Development of neurophysiological assessment for pain disorder
| Project/Area Number |
25461791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INUI Kouji 生理学研究所, 統合生理研究系, 准教授 (70262996)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 疼痛 / 生理学的指標 / 聴覚誘発反応 / 痛覚誘発反応 / 機能性障害 / 治療効果判定 / 身体症状症 |
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| Outline of Final Research Achievements |
Pain is a purely subjective experience and objective measurement is difficult. Thus, physiological indicators that can be quantified are important. In this project, we investigated the significance of convenient auditory and nociceptive stimulation and evoked cerebral responses. Firstly, it was shown that the P50 component reflects sensory memory, and the possibility that the change-related N1 / P2 component is related to the LDAEP was pointed out. Next, we developed the method to stimulate separately nociceptive Aδand Aβ fibers at the same site. By using this method, it was possible to evaluate the pain and the therapeutic effect functionally in pain-related diseases. Furthermore, we also examined psychological evaluation of somatic symptom disorder.
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| Free Research Field |
精神神経薬理学、臨床神経医学
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