2015 Fiscal Year Final Research Report
Evaluation of Lithium responsiveness and suicidality in mood disorders by near-infrared spectroscopy
| Project/Area Number |
25461792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJII Noa 近畿大学, 医学部, 准教授 (90460914)
KIRIME Eiji 近畿大学, 医学部, 講師 (80368307)
YANAGI Masaya 近畿大学, 医学部, 講師 (10418775)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | depression / bipolar disorder / suicide / lithium / NIRS |
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| Outline of Final Research Achievements |
We investigated the factors associated with lithium responsiveness and suicidality in mood disorders (bipolar disorder, depression) by brain function evaluated by the near-infrared spectroscopy and various clinical data.
The small number of cases with lithium responsiveness do not reach the statistical significance. On the other hand, we obtained significant results about suicidality as follows. 1) Discrepancies between self- and observer-rated depression severities are associated with vulnerability to suicide in patients with major depressive disorder, and prefrontal cortex activation is associated with these discrepancies. 2) Right temporal activation differs between melancholia and nonmelancholic depression. 3) Patients with bipolar disorders have persistent hypofunction of the frontotemporal cortical regions and the hemodynamic response in the left temporal regions is associated with symptom severity.
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| Free Research Field |
精神医学
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