Correlation between molecular biomarker and imaging findings in hepatocellular carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461805
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Matsui Osamu 金沢大学, 医薬保健学総合研究科, 特任教授 (10019961)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Satoshi 金沢大学, 大学院医薬保健学総合研究科, 教授 (30313638) ; Kozaka Kazuto 金沢大学, 大学院医薬保健学総合研究科, 助教 (80547175)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝細胞癌 / Gd-EOB-DTPA造影MRI / OATP1B3 / b-catenin mutation / HNF4a / 個別化医療

Outline of Final Research Achievements

The significant positive correlation between grades of OATP1B3 expression and enhancement ratio on hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging in hepatocellular carcinoma (HCC) was verified in this study. In addition, the highly significant correlation between HNF4a, b-catenin and OATP1B3 expression in HCC cells was also revealed. These results made it possible to sub-classify HCCs, resulting in possible application for future personalized medicine in the patient s with HCCs easily in daily practice.

Free Research Field

放射線医学