Establishing CT assessment of myocardial delayed enhancement and extracellular volume fraction with dual-source CT

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: KITAGAWA KAKUYA 三重大学, 医学部附属病院, 講師 (50378353)
• Co-Investigator(Kenkyū-buntansha): ISHIDA MASAKI 三重大学, 医学部附属病院, 助教 (10456741) ; NAKAYAMA RYOHEI 立命館大学, 理工学部, 准教授 (20402688) ; SAKUMA HAJIME 三重大学, 医学研究科, 教授 (60205797)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CT / 心臓 / 細胞外液分画

Outline of Final Research Achievements

We have developed a CT acquisition/reconstruction scheme for improved visualization of myocardial CT delayed enhancement that can also be used for the assessment of myocardial extracellular volume (ECV). ECV obtained with the proposed method demonstrated good reproducibility for all myocardial segments and demonstrated good correlation with ECV derived by MR T1 mapping. Furthermore, significant positive relationship was observed between age and ECV in patients without clinical coronary artery disease. We also developed a dictionary-based super-resolution technique to reduce radiation exposure and a software platform that can display voxel-based ECV map.

Free Research Field

医歯薬学