2016 Fiscal Year Final Research Report
Characterization of intratumoral hypovascular areas with PET and MRI
| Project/Area Number |
25461822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | PET / 腫瘍 / 低血流 |
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| Outline of Final Research Achievements |
Characteristics other than hypoxia in hypovascular areas inside the tumor were evaluated using images mainly on PET. Information on glucose metabolism was obtained from FDG PET. Association between increase in FDG uptake and decrease in blood flow was revealed in cases of primary liver tumors, and association between increase in FDG uptake and decrease in diffusion index from MR images was also clarified in pancreatic cancer cases. Intratumoral heterogeneity of FDG uptake was shown to be related to blood flow in pancreatic cancer, and showed the possible usefulness to predict treatment effect on chemotherapy and postoperative recurrence in esophageal cancer. Furthermore, texture analysis of intratumoral FDG uptake revealed that one texture feature allowed prediction of recurrence while it was not related to tumor volumes or degree of FDG uptake.
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| Free Research Field |
核医学
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