Molecular imaging of brain tumor with PET proliferation tracer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagawa University
• Principal Investigator: Yamamoto Yuka 香川大学, 医学部附属病院, 講師 (30335872)
• Co-Investigator(Kenkyū-buntansha): KUDOMI Nobuyuki 香川大学, 医学部, 准教授 (20552045) ; KAWAI Nobuyuki 香川大学, 医学部, 准教授 (40294756) ; NISHIYAMA Yoshihiro 香川大学, 医学部, 教授 (50263900) ; TOYOHARA Jun 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), その他部局等 (50425659)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 核酸誘導体 / PET / 分子イメージング / 脳腫瘍 / 11C-4DST

Outline of Final Research Achievements

A novel radiopharmaceutical, 11C-4DST, has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to evaluate 11C-4DST uptake in patients with glioma and to correlate the results with proliferative activity and tumor grade, in comparison with 11C-Methionine and 18F-FLT.
11C-4DST is feasible for imaging of brain gliomas, as well as 11C-Methionine and 18F-FLT. Especially, it showed the highest correlation coefficient between 11C-4DST and Ki-67 index in newly diagnosed gliomas.

Free Research Field

PET分子イメージング