An establishment of the diagnostic method of orbit malignant melanoma by the molecular imaging procedure using I-123 IMP

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Abe Koichiro 東京女子医科大学, 医学部, 教授 (00380387)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 眼窩悪性黒色腫 / IMP-SPECT / 診断 / 放射線治療

Outline of Final Research Achievements

The purpose of this study was to address the clinical value of N-isopropyl-p-[I-123]-iodoamphetamine SPECT (IMP-SPECT) in the diagnosis and in the follow-up after radiotherapy of ocular malignant melanoma (MM). Forty-three patients with clinically suspected ocular MM were examined and 16 patients (39.0%) were finally histopathologically diagnosed as MM. SPECT were taken at 15 min, 4 hr, 24 hr and 48 hr after IMP administration. All patients underwent IMP-SPECT and MRI and 12 of them underwent FDG-PET. We also picked up 15 MM patients who had IMP-SPECT several times before and after radiotherapy. At 48 hours after IMP administration, IMP-SPECT showed highest sensitivity (87.5 %) and accuracy (88.4%), that were higher than MRI and FDG-PET. On the other hand, IMP accumulation gradually decreased and finally disappeared 2-3 years after radiotherapy. This study shows that IMP-SPECT is useful tool for the diagnosis of ocular MM and for the follow-up of patients with MM after radiotherapy.

Free Research Field

核医学