Diffusion-weighted imaging-based thermometry in demyelinating diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461842
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka City University
• Principal Investigator: Miki Yukio 大阪市立大学, 大学院医学研究科, 教授 (80303824)
• Co-Investigator(Renkei-kenkyūsha): SAKAI Kouji 京都大学, 大学院医学研究科, 講師 (20379027) ; SHIMADA Hiroyuki 大阪市立大学, 大学院医学研究科, 特任教授 (90254391) ; SHIMONO Taro 大阪市立大学, 大学院医学研究科, 准教授 (70340817) ; TAKEDA Akitoshi 大阪市立大学, 大学院医学研究科, 講師 (90445015) ; SAKAMOTO Shinichi 大阪市立大学, 大学院医学研究科, 講師 (40464648)
• Research Collaborator: SAI Asari 大阪市立総合医療センター
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 脳 / 磁気共鳴画像 / MRI / 脱髄疾患 / 温度 / 月経周期 / 脳温度 / 拡散強調画像

Outline of Final Research Achievements

Brain temperature was measured using diffusion-weighted imaging-based MR thermometry of the lateral ventricles.
Our investigation revealed that brain temperature was significantly lower in MS patients (n=13) than in healthy controls (n=13). This probably represents decreased brain metabolism in MS patients. We also measured brain temperature of 20 healthy female volunteers (21.3-38.8 years of age) during both follicular and luteal phases, and found that brain temperature was significantly higher in luteal phase than in follicular phase.

Free Research Field

神経放射線診断学