Detection of cerebral microvascular lesions using 7 T MRI in patients with neuropsychiatric systemic lupus erythematosus.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: SASAKI Nobuhito 岩手医科大学, 医学部, 講師 (50382601)
• Co-Investigator(Kenkyū-buntansha): SASAKI Makoto 岩手医科大学, 超高磁場MRI診断・病態研究部門, 教授 (80205864) ; NAKAMURA Yutaka 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60328614) ; KOBAYASHI Hitoshi 岩手医科大学, 呼吸器アレルギー膠原病内科, 准教授 (60215358) ; MIZUNO Manori 岩手医科大学, 神経内科, 助教 (70382603) ; FUKUMOTO Kentarou 岩手医科大学, 精神神経科, 助教 (00514407)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 中枢神経ループス / 早期診断 / 7TeslaMRI

Outline of Final Research Achievements

On the high-resolution T1WIs obtained at 7 T, minute punctate/linear hyperintense lesions in subcortical and/or cortical areas were found in four (80%)neuropsychiatric systemic lupus erythematosus(NPSLE) patients and one (7%) non-NPSLE patient. Further, the minute punctate enhanced lesions in these areas were found on contrast-enhanced T1WIs in only three (60%) NPSLE patients. These findings suggesting microvascular thrombi or inflammation were significantly more frequent in NPSLE than in non-NPSLE patients (P=0.001). In contrast, other imaging findings, laboratory findings, and clinical characteristics were not different between the two groups. High-resolution T1WIs obtained at 7 T can detect minute lesions, indicating intracerebral microvascular lesions in patients with NPSLE.

Free Research Field

リウマチ膠原病