2015 Fiscal Year Final Research Report
Formulation of PET radiopharmaceuticals using solid phase extraction method
| Project/Area Number |
25461845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHOZUSHIMA Masanori 岩手医科大学, 歯科放射線学分野, 教授 (00118259)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA Ren 東北大学, サイクロトロンラジオアイソトープセンター, 教授 (60143038)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | PET / 放射性薬剤 / 固相抽出 |
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| Outline of Final Research Achievements |
Solid phase extraction (SPE) was used for the formulation of several PET radiopharmaceuticals as an alternative to the rotary evaporator methods. The SPE formulation process were optimized for dilution of the purified HPLC fraction with water, the selection of SPE cartridge, washing the cartridge with water, elution of the radiopharmaceutical with a small volume of ethanol and dilution with isotonic saline. The percentage of ethanol in the final solution was adjusted 2.5% (v/v) of volume. In all cases, a high radiochemical purity (>95%), residual organic solvent levels in the injectable solutions were below the recommended limits. The stability and the solubility of in the final solutions containing 2.5% of ethanol were maintained in practical time limit. The formulation by the SPE method enabled the efficiency and labor-saving in the manufacturing operation.
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| Free Research Field |
核薬学
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