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2016 Fiscal Year Annual Research Report

Preliminary studies on therapy of bone metastases by alpha-emitter radium-223

Research Project

Project/Area Number 25461854
Research InstitutionKindai University

Principal Investigator

細野 眞  近畿大学, 医学部附属病院, 教授 (00281303)

Project Period (FY) 2013-04-01 – 2017-03-31
Keywordsアルファ線 / Ra-223 / 放射線計測 / 線量評価 / 前立腺癌
Outline of Annual Research Achievements

アルファ線放出核種である塩化ラジウム-223(Ra-223)は骨に親和性を持っており、転移性骨腫瘍に対する新しいRI内用療法剤として開発され、最近、去勢抵抗性前立腺癌骨転移に対して全生存期間を延長する治療薬として国内外で臨床に導入された。本研究において平成28年度は、Ra-223の化学的物理学的特性を明らかにし、測定・計数や管理・汚染除去、線量評価などに関して取り扱う上での手法を確立するために、平成25-27年度に引き続き各種計測機器によるガンマ線と特性X線(光子)の計数、汚染を想定した汚染除去に関する実験、イメージングから線量評価への基礎検討を行った。本研究者の大学にはRa-223の使用許可を持つ実験室があり、各種の計測機器が備わっており、これらを用いてRa-223の測定の基本的事項を確認するとともに、測定の速度、時定数、距離などの条件を変えて、各タイプの計測機器で一般によく使われる機種を取り上げて測定の特性を調べた。また様々な素材を用いて、EDTAやRIクリーナの汚染除去能を調べた。成果としては、GM計数管、NaI(Tl)シンチレーション計数管、ZnS(Ag)検出器の特性を明らかにし、今回の検討の条件下で、GM計数管の方がNaI(Tl)シンチレーション計数管よりも計数効率がよい可能性のあることを示した。一方アルファ線用ZnS(Ag)検出器は距離が離れると計数効率が低く、Ra-223が放出する光子によってサーベイすることが妥当であることを示した。汚染除去に関しては、素材に付着したRa-223が乾燥してしまうといずれの除去剤を用いても除去されにくいため、早期の除去が重要であることを示した。Ra-223がわが国でも2016年3月28日に医薬品承認され、臨床の場で広く使われ始めたことから、本研究で得られた知見は重要であると考えられる。

  • Research Products

    (17 results)

All 2017 2016 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony2017

    • Author(s)
      Misaka T, Hosono M, Kudo T, Ito T, Syomura T, Uemura M, Okajima K
    • Journal Title

      Ann Nucl Med

      Volume: 31 Pages: 235-244

    • DOI

      10.1007/s12149-017-1151-x

    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical outcomes of IMRT planned with or without PET/CT simulation for patients with pharyngeal cancers2017

    • Author(s)
      Matsuura T, Nishimura Y, Nakamatsu K, Kanamori S, Ishikawa K, Tachibana I, Hosono M, Shibata T.
    • Journal Title

      Int J Clin Oncol

      Volume: 22 Pages: 52-58

    • DOI

      10.1007/s10147-016-1034-5

    • Peer Reviewed
  • [Journal Article] A new shielding calculation method for X-ray computed tomography regarding scattered radiation2016

    • Author(s)
      Watanabe H, Noto K, Shohji T, Ogawa Y, Fujibuchi T, Yamaguchi I, Hiraki H, Kida T, Sasamura K, Katsunuma Y, Nakano T, Horitsugi G, Hosono M
    • Journal Title

      Radiological Physics and Technology

      Volume: 1 Pages: 1-14

    • DOI

      10.1007/s12194-016-0387-9

    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head2016

    • Author(s)
      Sakaguchi k, Hosono M, Imamura T, Takahara N, Hayashi M, Yakushiji Y, Ishii K, Uto T, Murakami T
    • Journal Title

      EJNMMI Phys

      Volume: 3 Pages: 1-9

    • DOI

      10.1186/s40658-016-0164-1

    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Report of a nationwide survey on actual administered radioactivities of radiopharmaceuticals for diagnostic reference levels in Japan2016

    • Author(s)
      Watanabe H, Ishii K, Hosono M, Imabayashi E, Abe K, Inubushi M, Ohno K, Magata Y, Ono K, Kikuchi K, Wagatsuma K, Takase T, Saito K, Takahashi Y
    • Journal Title

      Ann Nucl Med

      Volume: 30 Pages: 435-444

    • DOI

      10.1007/s12149-016-1079-6

    • Peer Reviewed
  • [Journal Article] RI内用療法の将来展望と提言2016

    • Author(s)
      東 達也、池渕秀治、内山眞幸、織内 昇、絹谷清剛、細野 眞
    • Journal Title

      核医学

      Volume: 53 Pages: 27-43

    • Peer Reviewed
  • [Presentation] . Clinical evaluation and optimization of a new PET reconstruction algorithm Q.Clear in lung cancer2017

    • Author(s)
      Otani T, Hosono M, Kanagaki M, Fukumoto G, Onishi Y, Matsubara N, Kimura H
    • Organizer
      ECR 2017
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2017-02-28 – 2017-03-04
  • [Presentation] Theranostics: イメージングと治療の融合2016

    • Author(s)
      細野 眞
    • Organizer
      第56回日本核医学会学術総会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Year and Date
      2016-11-03 – 2016-11-05
    • Invited
  • [Presentation] Survey and decontamination of radium-223 dichloride for alpha- particle radionuclide therapy in clinical facilities2016

    • Author(s)
      Hosono M, Hohara S, Inagaki M, Yamanishi H, Wakabayashi G, Matsuda T, Sakaguchi K, Hanaoka K, Ito T
    • Organizer
      Annual Congress of European Association of Nuclear Medicine
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-10-15 – 2016-10-19
    • Int'l Joint Research
  • [Presentation] Estimation of administered fluorodeoxyglucose activity in patients on the basis of dose equivalent rate on head by multiple regression analysis2016

    • Author(s)
      Hosono M, Sakaguchi K, Imamura T, Takahara N, Hayashi M, Hosokawa C, Yamada M, Ishii K
    • Organizer
      Annual Congress of European Association of Nuclear Medicine
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-10-15 – 2016-10-19
    • Int'l Joint Research
  • [Presentation] Survey on radionuclide therapy facilities in Japan with grants by Ministry of Health, Labour, and Welfare2016

    • Author(s)
      Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yanagida S, Kitaoka
    • Organizer
      Annual Congress of European Association of Nuclear Medicine
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-10-15 – 2016-10-19
    • Int'l Joint Research
  • [Presentation] JSNM Education, Accreditation, and Multidisciplinary Team Practice2016

    • Author(s)
      Hosono M
    • Organizer
      Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2016-06-11 – 2016-06-15
    • Int'l Joint Research / Invited
  • [Presentation] Texture analysis for FMISO PET/CT in oncology patients receiving extra-beam radiation therapy2016

    • Author(s)
      Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Sakaguchi K, Ishikawa K, Nakamatsu K, Kanamori S
    • Organizer
      Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2016-06-11 – 2016-06-15
    • Int'l Joint Research
  • [Presentation] Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy2016

    • Author(s)
      Hanaoka K, Hosono M, Tatebe H, Ishikawa K, Monzen H, Ishii K, Nishimura Y
    • Organizer
      Annual Meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2016-06-11 – 2016-06-15
  • [Presentation] Dose evaluation and control for Nuclear Medicine2016

    • Author(s)
      Hosono M
    • Organizer
      Japan Radiology Congress 2016
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2016-04-14 – 2016-04-17
    • Int'l Joint Research / Invited
  • [Book] 新版放射線医科学2016

    • Author(s)
      細野 眞
    • Total Pages
      189
    • Publisher
      医療科学社
  • [Remarks] 医療放射線と未来

    • URL

      http://positron.me

URL: 

Published: 2018-01-16  

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