Preliminary studies on therapy of bone metastases by alpha-emitter radium-223

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kindai University
• Principal Investigator: HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
• Co-Investigator(Renkei-kenkyūsha): HOHARA Shinya 近畿大学, 原子力研究所, 准教授 (90434860)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ラジウム-223 / radium-223 / α線 / 放射線計測 / 線量評価

Outline of Final Research Achievements

The alpha-emitter radium-223 (Ra-223), which has an affinity to the bone, has been introduced into clinical practices as a therapeutic radiopharmaceutical that prolongs overall survival in castration-resistant prostate cancer with bone metastases. In this study, we conducted studies on measurements of photons by various counting devices in order to clarify the physiochemical properties of Ra-223, on decontamination methods assuming contamination of materials, and also appropriate parameters for imaging by gamma camera. We demonstrated the characteristics of GM counters，Na(Tl) scintillation counters, and a ZnS(Ag) counter, the importance of early decontamination of materials, and feasibility of gamma rays and characteristic X rays for imaging.

Free Research Field

放射線医学