Establishment of effective mixed umbilical cord blood transplantation for lethal dose radiation exposure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hirosaki University
• Principal Investigator: Ito Koichi 弘前大学, 保健学研究科, 教授 (90398579)
• Co-Investigator(Kenkyū-buntansha): NAKANO Manabu 弘前大学, 保健学研究科, 助教 (10436016)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 被ばく医療 / 臍帯血移植 / 免疫系再構築

Outline of Final Research Achievements

Hematopoietic stem cell transplantation is a powerful treatment that can be used to reconstitute hematopoietic systems damaged by accidental exposure to a lethal dose of radiation. Although umbilical cord blood cells (UCBCs) are an excellent transplant source, only a small number of cells can be obtained from a single umbilical cord. Mixed UCBC transplantation can overcome this limitation. In the present study using a murine model, we examined whether mixed UCBC transplantation would be suitable for radiation emergency medicine. Interestingly, a higher life-saving effect was obtained when allogeneic cord blood sources were mixed. In addition, such allogeneic mixed UCBC transplantation had the effect of restoring the recipient’s own hematopoietic system after exposure to a lethal dose of radiation. These results suggest the effectiveness of allogeneic umbilical cord blood as a source for mixed UCBC transplantation at centers specializing in radiation emergency medicine.

Free Research Field

免疫学