Development of a practical microreactor synthesys method of 11C-probes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461870
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: ISHIKAWA Yoichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (60361200)
• Co-Investigator(Kenkyū-buntansha): IWATA Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (60143038)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マイクロリアクター合成 / 分子イメージング / PET / 分子プローブ / 自動合成 / methyl triflate / Radiosynthesys / PET probe

Outline of Final Research Achievements

A rapid automated microreactor system was developed for 11C-methylation with 11C-methyl triflate (11C-MT). 11C-MT was flowed through a small diameter tube where it was trapped by thermoelectric cooling. It was then released and recovered with a small volume of suitable solvent such as acetone or acetonitrile. The 11C-MT was thus concentrated in a good recovery yield with optimized conditions and successfully applied to microreactor preparation of 11C-raclopride.

Free Research Field

医歯薬学