Medical use of effect of cavitation reinforced by a large amount of nanobubble: Evaluation by thrombolytic efficacy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kansai Medical University
• Principal Investigator: Kariya Shuji 関西医科大学, 医学部, 准教授 (40368220)
• Co-Investigator(Renkei-kenkyūsha): NAKATANI Miyuki 関西医科大学, 医学部, 助教 (10533424)
• Research Collaborator: INOUE Michito 松原動物病院, 獣医師 ; KONO Yumiko 関西医科大学, 医学部, 助教
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: キャビテーション / ナノバブル / 血栓溶解

Outline of Final Research Achievements

The thrombolytic effect was confirmed in the thrombosed vascular when a large amount of nanobubbles were generated using a manual nanobubble generator and the ultrasound was irradiated. The manual nanobubble generator was invented and the patent was applied for. It was proven to be able to administer the nanobubble into the small animal with the manual nanobubble generator in the experiment.
An extremely high density nanobubble can be supplied with a small amount of liquid with the manual nanobubble generator. Thus an extremely high effect of cavitation was able to be generated by ultrasound irradiation in the test tube and petri dish. It may be feasible even by the experiment by the microenvironment in the in vitro of surroundings such as cells in the future.

Free Research Field

Interventional Radiology