2015 Fiscal Year Final Research Report
New method to estimate brain damage and altered brain function due to radiotherapy in the patients with brain metastasis
| Project/Area Number |
25461900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Yoshihiro 弘前大学, 大学院医学研究科, 教授 (50107653)
TSUSHIMA Megumi 弘前大学, 大学院保健学研究科, 助教 (90592254)
YOSHIDA Hideki 弘前大学, 大学院保健学研究科, 准教授 (20400145)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳血流機能画像 / 脳転移 / 放射線治療 / 脳血流低下 / 認知機能低下 / 全脳照射 |
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| Outline of Final Research Achievements |
We investigated the availability of stereotactic statistical analysis of brain perfusion SPECT using 3-dimensional stereotactic surface projections (3D-SSP) to estimate the influence of radiation on brain function. The subjects were 12 with brain metastases. Whole brain, partial brain, and stereotactic radiotherapy (WBRT, PBRT and SRT) were delivered. Before and after radiotherapy, MRI, 3D-SSP and mini-mental state examination (MMSE) were performed. Regional cerebral blood flow (rCBF) decreased in the areas of tumor. For 6, 3D-SSP and MMSE were serially analyzed. Two of the 4 who received WBRT showed diffusely decreased rCBF, as well as decreased MMSE score. The remnant 2 showed no changes for both. One who received PBRT showed decreased rCBF, but the MMSE score was maintained. The other receiving SRT showed no change in rCBF, though the MMSE score decreased. Radiotherapy possibly has a risk to decrease rCBF, detected by 3D-SSP analysis.
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| Free Research Field |
放射線腫瘍学
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