2015 Fiscal Year Final Research Report
Development of less invasive and high-precision frameless stereotactic irradiation for intracranial vascular malformations
| Project/Area Number |
25461911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Asahi University (2014-2015)
Gifu University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 定位放射線治療 / 高精度放射線治療 / 低侵襲治療 / 脳卒中 / 脳動静脈奇形 |
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| Outline of Final Research Achievements |
This study was conducted to establish less invasive and more precise delivery methods in image-guided frameless stereotactic irradiation utilizing general linac platforms equipped with image-guidance for intracranial vascular malformations. To ensure accurate target delineation, the optimal method for integration of 3D rotational angiogram into planning images was examined and established via resconstructed cone-beam CT dataset inclusing phantom-based examinations. The implementation method for 6D adjustable image-guidance systems was also optimized via intra-fractional verification and correction.
Clinical application was conducted via two different platforms, and the immobilization stability was suitable in both systems. Inverse planning with Monte Carlo engine for dose calculation was also useful for generating further optimal dose distribution and more reliable dose calculation.
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| Free Research Field |
放射線腫瘍学
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