synchrotoron micro beam irradiation for tumors and normar tissue

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Nishimura Hideki 神戸大学, 医学(系)研究科(研究院), 准教授 (80444610)
• Co-Investigator(Kenkyū-buntansha): SASAKI Ryohei 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Kenji 神戸大学, 医学部附属病院, 講師 (80351906)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Spring－8 / 格子状照射 / マイクロビーム / 放射線治療 / 放射光

Outline of Final Research Achievements

Micro beam radiation therapy (MRT) allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) is still unknown. We evaluated mortality in normal mice following CNS-targeted MRT. MRT using synchrotron X-ray beam was performed using BL28B2 beam-line at the SPring-8 facility. Fifty percent lethal dose by the 300 micrometer spacing MRT was 600 Gy. Our results indicated that the MRT enable to deliver extremely high doses without loss of normal brain function. Our results suggest that normal tissue damage in MRT is related to the valley dose in regardless of the peak dose and peak valley dose ratio.

Free Research Field

放射線腫瘍学