Development of a novel enzyme-targeting radiosensitizer (New KORTUC) using a gelatin-based hydrogel instead of a siduim hyaluronate

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461916
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kochi University
• Principal Investigator: OGAWA YASUHIRO 高知大学, その他の部局等, 名誉教授 (90152397)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線増感剤 / KORTUC / 過酸化水素 / ヒアルロン酸 / ハイドロゲル / 架橋ゼラチン / 腫瘍低酸素 / 放射線抵抗性

Outline of Final Research Achievements

We recently developed KORTUC as a strategy to increase intratumoral oxygen concentrations and degrade antioxidant enzymes such as peroxidase and catalase. We then developed KORTUC II, which uses sodium hyaluronate containing hydrogen peroxide as a radiosensitizer. KORTUC II requires twice-weekly administration to sustain its effects, but decreasing the frequency of radiosensitizer injections to once-weekly would reduce the burden on the patients and the physicians. The goal of this study was thus to develop a new formulation of KORTUC (New KORTUC) that only requires once-weekly administration. We performed experimental studies using a mouse tumor model and biodegradable hydrogel. Tumor growth rate was slowest in the hydrogel groups. These data suggest that hydrogel could represent a useful adjunct as a long-acting radiosensitizer in place of sodium hyaluronate. Use of this new formulation allows radiosensitizer injections to be performed once-weekly with good effect.

Free Research Field

放射線腫瘍学