Establishment of optimal dose schedule with high precision definitive radiotherapy for patients with uterine cervical cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of the Ryukyus
• Principal Investigator: Takafumi TOITA 琉球大学, 医学(系)研究科(研究院), 准教授 (30237036)
• Co-Investigator(Kenkyū-buntansha): KASUYA Goro 琉球大学, 医学部附属病院, 医員 (00639932) ; OHNO Tatsuya 群馬大学, 学内共同利用施設等, 教授 (10344061) ; KAKINOHANA Yasumasa 琉球大学, 大学院医学研究科, 助教 (20185713) ; TAKASHI Uno 千葉大学, 医学研究科, 教授 (30302540) ; SATOSHI Ishikura 順天堂大学, 医学部, その他 (40407242) ; ARIGA Takuro 琉球大学, 医学部附属病院, 助教 (60647337)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 子宮頸癌 / 放射線治療 / 高線量率腔内照射 / 臨床試験

Outline of Final Research Achievements

Definitive radiotherapy (RT) and chemoradiotherapy (CRT) are now considered a global standard of treatment for patients with uterine cervical cancer. In RT/CRT, the difference in total radiotherapy dose between Japan and other countries has been a critical issue. We conducted two multi-institutional clinical trials to evaluate the clinical results with the Japanese dose, and we demonstrated favorable outcomes with less severe toxicities. However, some international investigators criticized these results because there was uncertainty about the dose evaluation for the Japanese external beam RT that uses central shielding. In order to remove the doubts, we developed a clinical study adopting a new external beam RT protocol without central shielding, and we have started recruiting patients.

Free Research Field

放射線腫瘍学