2016 Fiscal Year Final Research Report
The study of organ preservation solutions and oxygenated machine perfusion preservation with temperature controlled for porcine DCD liver graft
| Project/Area Number |
25461939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 心停止ドナー / 肝臓保存 / 灌流保存方法 / 人工赤血球含有灌流液 |
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| Outline of Final Research Achievements |
Utilization of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor pool. To assess potential effect, porcine livers procured after 60 minutes of warm ischemic time were perfused and preserved. Study 1; The effects of subnormotherc preservation(SNP) with machine preservation(MP) Study 2;Evaluation of HES or PEG in UW gluconate solution of porcine liver grafts Study 3; Impact of solution containing artificial oxygen carrier hemoglobin vesicles(AOC).Results 1; According to increase the preservation temperature, more oxygen consumption was required and portal vein pressure was decreased. The changes of AST, LDH and hiarulonic acid were lowest in SNP. Potentially, SNP is expected to help the recovery of function. Results 2; Effluent enzyme of AST and LDH were lower in PEG group HES may not be effect as a MP solution. Results 3; MP solution containing with AOC is expected to use the recovery the function.
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| Free Research Field |
肝胆膵・移植外科
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