Studies on subcutaneous transplantation therapy for diabetes using mesenchymal stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461943
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: SUMI Shoichiro 京都大学, 再生医科学研究所, 准教授 (80252906)
• Co-Investigator(Renkei-kenkyūsha): SHIROUZU Yasumasa 京都大学, 再生医科学研究所, 講師 (20279186)
• Research Collaborator: YANAI Goichi 京都大学, 再生医科学研究所, 研究員 ; KAWAGOI Masako 京都大学, 再生医科学研究所, 研究員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵島移植 / 間葉系幹細胞 / 細胞融合 / バイオ人工膵島 / マクロカプセル化 / 皮下移植

Outline of Final Research Achievements

Mesenchymal stem cell (MSC) is known for cell-protective and inflammation-regulating effects. Electro-fusion of MSCs and islet cells resulted in new cells possessing growth ability and anti-apoptotic function in addition to islet like cell function of glucose-responsive insulin release. In order to utilize various islet-like cells/tissues including these fusion cells, innovative macro-encapsulation system for immuno-isolation was developed together with neovascularization-indusing method to realize subcutaneous transplantation. These results formed the basis for clinical subcutaneous transplantation of islets or islet-like cells/tissues.

Free Research Field

代謝内分泌疾患に対する再生医療