2015 Fiscal Year Final Research Report
The suppressive mechanism of liver immune reactivity after islet transplantation by mesenchymal stem cells
| Project/Area Number |
25461948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 糖尿病 / 移植 / 免疫 |
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| Outline of Final Research Achievements |
Islet transplantation is considered as one of the standard therapy against type 1 diabetes melitus. The purpose of this study is to develop a new immunesuppressant treatment for improvement of islet graft engraftment by regulation of liver immune response after islet transplantation.
We confirmed that cytotoxic activity of natural killer (NK) cells in the liver were increased after intraportal islet transplantation and activation of NK cells prevent islet graft better engraftment in the murine model. In this study, we focused on the mesenchymal stem cells (MSCs) which possess the immune suppressive function for suppression of the NK cells activation after ielet transplantation. The simultaneous administration of MSCs with islet into the portal vein showed prolonged islet graft survival and the suppressive effect of activated liver NK cells after islet transplantation when compared with islet transplantation alone.
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| Free Research Field |
移植
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