The analysis of deceased donor split liver transplantation in Japan

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: National Center for Child Health and Development (2013, 2015); Kumamoto University (2014)
• Principal Investigator: Sakamoto Seisuke 国立研究開発法人国立成育医療研究センター, その他部局等, その他 (00378689)
• Co-Investigator(Kenkyū-buntansha): Kasahara Mureo 国立成育医療研究センター, 臓器移植センター, センター長 (30324651) ; Uemoto Shinji 京都大学, 医学研究科, 教授 (40252449) ; Inomata Yukihiro 熊本大学, 大学院生命科学研究部, 教授 (50193628) ; Ogura Yasuhiro 名古屋大学, 医学部付属病院, 准教授 (20335251)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脳死臓器提供 / 分割肝移植 / ドナー / レシピエント

Outline of Final Research Achievements

According to the analysis of deceased donor split liver transplantation (SLT),including 36 cases undergoing the operation by the end of 2014, the outcome was satisfactory and compatible with the previously published data. However, the incidence of surgical complications was relatively high, and those complications tended to occur in the patients receiving right-sided split grafts. In terms of the donor criteria for SLT, it would be suitable to use the Western countries' criteria, including donor age (younger than 50 years), liver function tests (within 3 times of the upper normal limits), and less than mild steatosis. Critically-ill patients and retransplant patients have to be avoided as SLT recipient candidates, although it would not be possible to be applied at present owing to the shortage of deceased donor organs. The splitting procedure may be reconsidered to prevent surgical complications and in-situ splitting procedure may be favorable instead of ex-vivo splitting procedure.

Free Research Field

移植外科学