2015 Fiscal Year Final Research Report
Novel treatment for chromothripsis in breast cancer
| Project/Area Number |
25461978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGINO MASATO 名古屋大学, 医学系研究科, 教授 (20237564)
YOKOYAMA YUKIHIRO 名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO TOSHIO 名古屋大学, 医学系研究科, 特任講師 (60378023)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Chromothripsis |
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| Outline of Final Research Achievements |
Chromothripsis has not been identified in breast cancer and bone tumor cell lines. Anti-cancer agents are not able to induce chromothripsis in cancer cell lines, including breast, colorectal and pancreatic cancer cell lines.
Fusion genes are a genetic variation similar to chromothripsis.We identified several fusion genes, including two non-coding RNAs (LOC642236 and LOC283788). Because there are no fusion genes in normal cells, fusion genes are an appropriate target for molecular targeted therapy; therefore, novel treatment therapies involving the above fusion genes are expected in the future.
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| Free Research Field |
外科学
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