Experimental and clinical study for free dermal fat grafting technique during breast conserving surgery in patients with breast cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kagoshima University
• Principal Investigator: Kijima Yuko 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (60381175)
• Co-Investigator(Kenkyū-buntansha): HIRATA MUNETUGU 鹿児島大学, 医歯学域医学部・歯学部附属病院, 医員 (00649072) ; NAKAJO AKIHIRO 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (20404486) ; NATSUGOE SHOJI 鹿児島大学, 医歯学域医学系, 教授 (70237577) ; SHINDEN YOSHIAKI 鹿児島大学, 医歯学域医学部・歯学部附属病院, 医員 (20725733) ; ARIMA HIDEO 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (90418856)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 乳癌 / 乳房温存手術 / 遊離真皮脂肪片 / 整容性

Outline of Final Research Achievements

①We made an rat model and clarified free dermis fat single (FDFG) survival mechanism scientifically. [Mizoguchi T, et al.Surgery Today (2014:22)]. There was significantly fewer apoptosis and more VEGF-positive cells in the FDFG group. Attached dermis would play an important role in a vascularization and the prevention of apoptosis.
②We revealed the risk factor of postoperative complication in FDFG implanted cases. [Kijima Y, et al. Gland Surgery 2015(4)]. This study were clinically done as a multi-institutional joint research in Japan and it is the first report in the wolrd to discuss the risk factor and indication for this operation using multi-institutional data.

Free Research Field

医歯薬学