2016 Fiscal Year Final Research Report
Identification of breast cancer-specific signatures in saliva metabolites using capillary electrophoresis mass spectrometry
| Project/Area Number |
25461996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Teikyo University (2015-2016)
Keio University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 唾液 / メタボローム / 乳癌 / 診断 / CE-TOFMS |
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| Outline of Final Research Achievements |
The aim of this study is to identify breast cancer-specific signatures in saliva metabolites to facilitate the early diagnosis of breast cancer.
Comprehensive metabolite analysis of saliva was conducted using capillary electrophoresis time-of-flight mass spectrometry. Saliva samples were obtained from 20 healthy controls and 90 breast cancer patients. Among 205 peaks identified from the salivary metabolites, 62 salivary biomarkers demonstrated significantly higher concentrations in breast cancer patients comparing with healthy individuals (p<0.05). Known markers such as N1-acetylspermidine, spermine, putrescine and N8-acetylspermidine were included in these 62 markers.
These data suggested that quantitative information for salivary metabolites and their combinations could be promising biomarkers for the early diagnosis of breast cancer.
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| Free Research Field |
乳腺外科, 外科腫瘍学
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