Duodenal jejunal bypass improves non-alcoholic steatohepatitis (NASH) in diet induced NASH model rats

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: Naitoh Takeshi 東北大学, 医学(系)研究科(研究院), 准教授 (50291258)
• Co-Investigator(Kenkyū-buntansha): Shibata Chikashi 東北医科薬科大学, 医学部, 教授 (30270804) ; Tanaka Naoki 東北大学, 大学病院, 助教 (60547404)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: NASH / 減量手術 / 胆汁酸 / SREBP / FXR / 十二指腸空腸バイパス術 / Metabolic Surgery

Outline of Final Research Achievements

We previously developed diet-induced NASH rat model. In this model, we performed the duodena-jejunal bypass (DJB) as a metabolic surgery and confirmed that NASH of the rat was improved dramatically. In the DJB group, the serum bile acids were elevated and expression of FXR, which is the nuclear receptor of the bile acids, was up-regulated in the liver. FXR is known to regulate the expression of the several enzymes related to metabolism, such as gluconeogenesis or lipogenesis. SREBP1c regulates the expression of the lipogenic enzymes and it is regulated by FXR as well. In this model, the level of SREBP was down-regulated in the DJB model, but not reached to the significant level comparing to the control group. However, we can conclude that NASH can be improved by the DJB and bile acids elevation and following cascade is strongly related to this mechanism.

Free Research Field

減量手術