Effect of vagotomy on gastrointestinal motor activity and hormone after gastrectomy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Saitama Medical University
• Principal Investigator: Mochiki Erito 埼玉医科大学, 医学部, 教授 (80312883)
• Co-Investigator(Kenkyū-buntansha): Kyouichi Ogata 群馬大学, 医学部付属病院, 助教 (10448897) ; Takehiko Yokobori 群馬大学, 医学系研究科, 講師 (60420098) ; Hiroyuki Kuwano 群馬大学, 医学系研究科, 教授 (90186560)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃切除 / 消化管運動 / 神経温存 / モチリン / グレリン

Outline of Final Research Achievements

Post gastrectomy syndrome is a serious problem after gastrectomy. To improve post gastrectomy syndrome, variations of functional-preserving gastrectomy were performed. This study was performed to examine the influence of the vagus nerve on gastrointestinal function and hormone. Three types of animal model were prepared (control, truncal vagotmy and distal gastrectomy). The motility was recorded using strain gauge force transducers. A silastic tube was inserted into the gastric body or abdominal cavity for drug administration. Experiments were conducted 1 week after surgery. Interdigestive migrating motor contractions (IMC) was observed at interval of 90-100 minutes during interdigestive state. Motilin and ghrelin agonist stimulated GI motor activities. However truncal vagotomy inhibited an appearance of IMC and motilin induced motor activity. We concluded that vagus was a major modulating system for motilin induced motor activity.

Free Research Field

胃外科