Elucidation of specific lncRNA of lymph node metastases in gastric cancer for surgical individual treatment for the gastric cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Ohi Masaki 三重大学, 医学(系)研究科(研究院), 講師 (40418752)
• Co-Investigator(Kenkyū-buntansha): Kusunoki Masato 三重大学, 医学系研究科, 教授 (50192026) ; Mohri Yasuhiko 三重大学, 医学系研究科, 准教授 (70345974) ; Toiyama Yuji 三重大学, 医学系研究科, 講師 (00422824)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: lncRNAs / gastric cancer / lymph node metastases / peritoneal dissemination / lncRNA X

Outline of Final Research Achievements

We have found out lncRNAs, which had high utility to be involved in metastatic formation so far to elucidate the mechanism of lymph node metastases of gastric cancer. As a result, we were able to identify lncRNA X with the strong association with lymph node metastases and peritoneal dissemination. We showed overexpression of lncRNA X in a gastric cancer tissue as compared with normal mucosa and showed that the expression of lncRNA X is the independent prognostic factor of the survival period. In addition, this lncRNA X was an independent risk factor of the peritoneal dissemination. Furthermore, as a result of having tested participation in growth of lncRNA X in vivo experiment, tumor enlargement was significantly inhibited in the gastric cell lines that were controlled by siRNA to lncRNA X.

Free Research Field

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