2016 Fiscal Year Final Research Report
The development of tumor microenvironment-directed chemotherapy with molecular targeted agent for gastrointestinal cancer
| Project/Area Number |
25462019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
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| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 消化器癌 / がん幹細胞 / 浸潤・転移 / 低酸素状態 / 血管新生 |
|---|
| Outline of Final Research Achievements |
We analyzed the change of expression level of HIF-1 and PD-L1 in rectal cancer tissue by chemoradiotherapy. As the expression level of HIF-1 and PD-L1 increased in some cases after chemoradiation, HIF-1 seemed to upregulate the expression of PD-L1. The expression of PD-L1 in tumor cells associated with unfavorable overall survival, and the expression of PD-L1 in lymphocytes around tumor was considered to suppress lymph node metastasis in rectal cancer.
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| Free Research Field |
消化器外科学
|
