2015 Fiscal Year Final Research Report
Chemoradiotherapy for eshophageal cancer using down-regulation of micro RNA
| Project/Area Number |
25462022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
Hihara Jun 広島大学, 原爆放射線医科学研究所, 講師 (10322744)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 食道癌 |
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| Outline of Final Research Achievements |
Tumor-specific immunoreaction may play an important role in chemoradiotherapy for esophageal cancer. In esophageal squamous cell carcinoma cell lines, down-regulation of miR-222 and miR-339 might has a potential to up-regulate ICAM-1 expression. These micro RNAs might be candidates for molecular targets to enhance anti-tumor effect in chemoradiotherapy for esophageal cancer with T-cell infiltration.
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| Free Research Field |
消化器外科
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