2015 Fiscal Year Final Research Report
Chemoradiotherapy for eshophageal cancer using down-regulation of micro RNA
Project/Area Number |
25462022
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Hiroshima University |
Principal Investigator |
Hihara Jun 広島大学, 原爆放射線医科学研究所, 講師 (10322744)
|
Co-Investigator(Kenkyū-buntansha) |
OKADA MORIHITO 広島大学, 原爆放射線医科学研究所, 教授 (70446045)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 食道癌 |
Outline of Final Research Achievements |
Tumor-specific immunoreaction may play an important role in chemoradiotherapy for esophageal cancer. In esophageal squamous cell carcinoma cell lines, down-regulation of miR-222 and miR-339 might has a potential to up-regulate ICAM-1 expression. These micro RNAs might be candidates for molecular targets to enhance anti-tumor effect in chemoradiotherapy for esophageal cancer with T-cell infiltration.
|
Free Research Field |
消化器外科
|