Analysis of novel gastric tumor suppressor RUNX3 for the clinical application of gastric cancer treatment

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: sakakura chouhei 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (10285257)
• Co-Investigator(Kenkyū-buntansha): OKUDA Tsukasa 京都府立医科大学, 医学研究科, 教授 (30291587) ; KODAMA Yuzou 京都大学, 医学研究科, 助教 (80373687)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃癌 / 癌抑制遺伝子 / 分子生物学 / 遺伝子診断 / 発癌予防

Outline of Final Research Achievements

Based on the analysis result of RUNX3 knockout mouse as well as clinical samples of gastric cancer, the following was developed aiming at the functional analysis of RUNX3, and gene diagnosis and the application to carcinogenic prevention and medical treatment.
We have already identified several kinds of markers of a gastric cancer precursor cell, and are looking for a stomach cancer precursor cell in the background membrane of an early frequent occurrence stomach cancer excision specimen. Furthermore, RUNX3 has played the role important for TGFbeta dependence apoptosis (Oncogene, Sakakura et al., 2007). The molecule (TCF4) which the carcinogenic signal transfer system (Wnt signal system) of colorectal cancer and a RUNX3-TGFbeta signal transfer system overlap is also identified (Cancer Cell, Ito et al, 2009). With Luminex system, we establish the quick serological-diagnosis system which can measure quantitatively methylation of two or more genes in many samples in a short time.

Free Research Field

消化器外科