Therapeutic effect of suppresion of lymphatic invasion by regulating epithelial-mesenchymal transition in gastric cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: Wada Norihito 慶應義塾大学, 医学部, 講師 (40256087)
• Co-Investigator(Kenkyū-buntansha): HAYASHIDA Tetsu 慶應義塾大学, 医学部, 専任講師 (80327543)
• Co-Investigator(Renkei-kenkyūsha): KATO Fumihiko 慶應義塾大学, 医学部, 助教 (90573428)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃癌 / リンパ節転移 / リンパ管新生 / ＨＯＸＢ９ / 上皮間葉移行 / 浸潤能 / 幹細胞性 / リンパ管新生

Outline of Final Research Achievements

In this study, we investigated the therapeutic effect of suppression of lymphatic invasion by regulating epithelial-mesenchymal transition (EMT) in gastric cancer. Clinicopathological study using gastric cancer specimen revealed that patients with HOXB9 expression have higher node metastasis and vascular/lymphovascular infiltration. HOXB9 positive group had worse overall survival, as well. We established a gastric cancer cell line TMK-1 with HOXB9 gene and showed higher level of lymphangiogenic factors using RT-PCR. HOXB9 would be a promising molecule which could suppress the gastric cancer progression in the aspect of lymphatic invasion.

Free Research Field

一般・消化器外科